The Flintstones

Dexter's Laboratory
In "Dad is Disturbed" Betty Rubble is apparently shown speaking to Dexter's mom.

No

Drawn Together
In the Comedy Central animated film The Drawn Together Movie: The Movie!, she can be seen trying to kill Toot Braunstein (she misses and shoots a dinosaur instead), for finding out that her husband Barney Rubble cheated on her and got Toot impregnated (Toot's baby is revealed to be Bamm-Bamm Rubble).

No

I Am Weasel
Betty has been seen in the episode I Am My Lifetime, where she is placed in the Retirement Home for Sidekicks (which is actually Baboon's trailer).

No